La lettre d'information du Réseau international des instituts Pasteur
 
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RIIP-Info
 
The Institut Pasteur
International Network Newsletter
 
September 2019
 
NEWS
The scientific teams of the Institut Pasteur International Network involved in the fight against the Ebola epidemic in the DRC
 
 
Through the expertise of the Institut Pasteur de Dakar and several of its researchers currently deployed in the Democratic Republic of Congo (DRC) as they had been throughout the Ebola epidemic in Guinea, the Institut Pasteur International Network is mobilized in the fight against the Ebola epidemic currently raging in the provinces of North Kivu and Ituri. This team of scientists from the WHO Collaborating Centre "Arbovirus and hemorrhagic fevers", participates in field diagnostics alongside the National Institute of Biomedical Research of the DRC (INRB). The Institut Pasteur in Dakar will continue to provide support in the response to this epidemic declared a "global public health emergency" by WHO since 17 July 2019.
 
Snake bites: launch of a study in Cameroon to evaluate anti-venomous sera
 
 
The study "Snake Bites in Cameroon: Evaluation of Antivenomous Serum in Africa (ESAA) data collection in real life conditions" was launched on the 26th and 27th of June 2019 during a kick-off meeting held in Yaoundé. The study will run over over 2 years in 14 health centers in Cameroon. The ESAA study, coordinated by the Institut Pasteur, aims to evaluate the clinical safety and efficiency of an anti-venomous serum registered in Cameroon. Its implementation is the result of joint efforts by various partners such as IRD, Epicentre, the Cameroon Society of Epidemiology (CaSE) and the Société Africaine de Venimologie (SAV), under the aegis of the Cameroon Ministry of Public Health. Nearly 470 participants will be included in the study via the centers, which will gradually open from the beginning of August 2019.
 
The virulence strategy used by Leishmania unveiled
 
 
A team from INRS - Centre Armand-Frappier Santé Biotechnologie, has just made a scientific breakthrough concerning the virulence strategy used by the parasite Leishmania. This microorganism is responsible for a chronic parasitic disease affecting more than 12 million people worldwide: leishmaniasis. Professor Albert Descoteaux's group, in collaboration with researchers from McGill University, Université de Montréal and Tohoku University, demonstrate that Leishmania takes advantage of an intracellular transport mechanism already existing in macrophages to spread its virulence factors. Their work was published in the journal PLOS Pathogens.
 
Reptiles of Guadeloupe: reservoirs of major human salmonella serovars
 
 
Reptiles are known to be reservoirs for Salmonella bacteria. The team of the Microbial Ecosystems Interaction Laboratory in collaboration with the Enteric Pathogenic Bacteria Unit of the Institut Pasteur has shown that the epidemiology of salmonella infections in Guadeloupe is particular with serovars rarely isolated in hexagonal France (antigenic property allowing a cell or virus to be identified by serological methods). These serovars, found in reptiles but also in pigs, have a wide host spectrum and the transmission routes probably involve direct or indirect contact with animals. Another serovar isolated specifically from anolis has frequently been found in human cases suggesting a key role of these small lizards in the transmission of salmonella in Guadeloupe. This study is published in PLOS One.
 
A risk map for cutaneous leishmaniasis in humans in the neotropical forest biome
 
 
Researchers at the Institut Pasteur de la Guyane, in collaboration with the Centre Hospitalier de Guyane, the Lêonidas e Maria Deane and Evandro Chagas Institutes of Brazil and the University of Rosario in Colombia, have just published an article in PLOS Negleted Tropical Diseases with risk maps for skin leishmaniasis in humans on two different scales: in the biome of the neotropical rain forest (Amazon basin and surrounding forest ecosystems) and in Guyana. At both spatial scales, the most at risk areas are located where the human impact on the environment is significant. These areas have also been associated with contributing climatic and ecological factors.
 
Distribution and particularities of two Mycobacterium tuberculosis lines
 
 
The team from the Tuberculosis and Mycobacteria Unit of the Institut Pasteur de la Guadeloupe described the overall distribution and epidemiological characteristics of two main lines of Mycobacterium tuberculosis infecting patients. This study was carried out using the SITVIT2 database built by the same team. It concerns the "East-African-Indian" lineage (EAI - also known as Line 1 or Indo-Oceanic Lineage) and the "Central Asian" lineage (CAS - also known as Lineage 3). These results were published in PLOS One magazine.
 
TEACHING
2020 Vaccinology course
Date and place: February 10 – March 6 2020, Institut Pasteur in Paris, France
Application deadline: October 30, 2019
 
 
Co-directed by Armelle Phalipon and Béhazine Combadière, this four-week course offers an integrated overview of vaccinology, by covering all the key issues of vaccine development from design to delivery to the populations in industrialized and developing countries. It aims at providing the attendees with the knowledge required to become future actors of the international vaccine community.
 
CALL FOR APPLICATION
Intra-Network Grants Calmette & Yersin
Deadline for application : September 30, 2019
 
 
The Calmette & Yersin Intra-Network Grants, funded by the Department of International Affairs of Institut Pasteur and with a duration from 1 to 3 months, are dedicated to permanent scientists (researchers or engineers) from the Institut Pasteur International Network who wish to initiate, develop and/or consolidate a collaboration with a permanent researcher or engineer from another institute in the Network (except Institut Pasteur). The research project must be established jointly by the scientists, with the approval of the institutes involved. It will define the objective(s) of the collaboration, the relevance of the project regard to the state of the art and the impact of the expected results.
 
EVENTS
Symposium "Pasteur Network Fighting Emerging Threats"
Date and place : september 25, 2019, Institut Pasteur de Corée
 
 
Outbreaks of newly emerging viruses such as New Flu, Zika virus, and MERS virus, represent a constant threat to the global population. Emerging virus outbreaks have been ascribed to many factors, including climate change and the increased international travel. In particular, this symposium focuses on the vector-borne flaviviruses such as Dengue virus and Zika virus or Japanese encephalitis virus. Scientists from the Institut Pasteur and Asian regional institutes, including the Institut Pasteur of Shanghai, Chinese Academy of Sciences, the University of Hong Kong-Pasteur Research Pole, the Institut Pasteur de Nouvelle-Calédonie, will participate in this event.
 
Joint international symposium of the Institut Pasteur and the Kitasato Institute Kitasato University in Japan
Date and venue: October 2, 2019, Tokyo, Japan
 
 
The Institut Pasteur and The Kitasato Institute Kitasato University are co-organizing an international symposium on October 2, 2019, supported by the Pasteur Japan Foundation. Shibasaburo Kitasato, who is the founder of The Kitasato Institute, is known as the "father of Japanese bacteriology". He visited Louis Pasteur on his way back from Germany to Japan in 1892, and he received a signed portrait of Louis Pasteur. During this first joint symposium, participants will discuss influenza viruses, parasitology and disease vectors, as well as pathogenic bacteria.
 
INSTITUTIONAL
VIDEO: the Institut Pasteur in 2018
 
 
The year 2018 has been exceptional in several ways. It was marked by the celebration of the 130th anniversary of the Institut Pasteur and the arrival of a new President. The adoption of its 2019-2023 Strategic Plan offers a new ambition for the institute, and recalls that human health is at the heart of its mission.
 
 
* Next RIIP-Info on October 2019 *
 
 
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