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The Institut Pasteur
International Network Newsletter
April 25, 2019
A new bacteria-killing weapon in the fight against antibiotic resistance
When the first antibiotics were discovered in the early 20th century, the rate of death from infectious diseases fell dramatically. But the emergence of multidrug-resistant bacteria as a result of antibiotic misuse is raising fears that by 2050, these same diseases will once again become the leading cause of death worldwide. In a bid to boost the arsenal available to tackle this threat, scientists from the Institut Pasteur, the CNRS and the Universidad Politécnica de Madrid successfully programmed a bacterial genetic structure to make it capable of specifically killing multiple antibiotic-resistant bacteria without also destroying bacteria that are beneficial to the body. Unlike other approaches under development, this novel tool is associated with a minimal rate of emergence of new resistance. The results were published in the journal Nature Biotechnology.
Dr Amy Kristine Bei to head a new 4-year research group on malaria in Dakar
A new 4-year research group (G4), set-up at the Institut Pasteur de Dakar, in collaboration with the Yale School of Public Health, started in early February, following the agreement signed between the Institut Pasteur and AUF (Agence universitaire de la francophonie) on 31 January 2019. Entitled « Malaria Experimental Genetic Approaches and Vaccines », it will be led by malaria researcher Dr Amy Kristine Bei, an Assistant Professor at the Yale School of Public Health. The objective of this 4-year research group (G4) is to understand the interaction between parasite diversity and immune selection, helping to to identify the most promising vaccine candidates.
Opening of a rabies prevention centre in Kampong Cham, Cambodia
A new rabies prevention centre in Kampong Cham, Cambodia. The Institut Pasteur du Cambodge, in collaboration with the Provincial Health Department (PHD) and the provincial hospital where it is temporarily located, has opened the doors of this centre to the public on March 7. Managed by two doctors and two nurses, it welcomes nearly 100 new patients per day, injured by animals. In 2018, a rabies prevention centre was opened in Battambang with the aim of vaccinating an average of 10,000 people per year.
The emergence of multidrug-resistant tuberculosis now under high surveillance in Central Africa
The Central African Republic is among countries, with the highest burden of tuberculosis world-wide, with an incidence of 423 cases per 100,000 population. The country is also facing the emergence of multidrug-resistant tuberculosis. In 2015, the Institut Pasteur de Bangui introduced rifampicin resistance monitoring using the GeneXpert MTB / RIF technique and published a first report after 3 years of activity.
In the media: Wolbachia, a bacterium attacking dengue fever
The World Mosquito Program WMP consortium, which brings together the City of Noumea, the DASS of New Caledonia, the University of Monash (Australia) and the Institut Pasteur de Nouvelle-Calédonie, plans to release mosquitoes in Nouméa that carry Wolbachia, a bacterium blocking the development of arboviruses in the vector. Scientists at the "dengue and arboviroses" unit, headed by Myrielle Dupont Rouzeyrol and Nicolas Poquet's medical entomology unit are currently testing that the bacteria implanted in mosquitoes block the dengue, Zika and Chikungunya viruses. The objective is to gradually spread the bacterium among all mosquitoes that mate in order to render the Aedes aegypti population incapable of transmitting the aforementioned viruses. The local journal “Les Nouvelles Calédoniennes” published a report on the WMP, which should start next summer at the Institut Pasteur de Nouvelle- Calédonie, including the statement of Anna Bella Failloux, head of the Arbovirus Unit at the Institut Pasteur in Paris.
Partnership within IPIN: two new “Pasteur International joint research Units” 2019
Application deadline : June 7, 2019
To strengthen the partnership with institutes from the Institut Pasteur International Network (IPIN), the Institut Pasteur (IP) will support the creation of two “Pasteur International Joint Research Units” (PIU/IP-RIIP). A PIU/IP-RIIP is a “Virtual Unit” that aims to bring together two or more research teams belonging to IPIN including one or more from IP, to pool their complementary skills and expertise and build research programs on topics of common interest. The PIU/IP-RIIP will be supported for 5 years. The application must be submitted by a group leader or head of unit/G5 of Institut Pasteur. Proposed projects must comply the IP and IPIN scientific strategy, addressing a priority public health issues in countries where RIIP institutes are based.
Calmette & Yersin Postdoctoral Grant
Application deadline : July 13, 2019
The Calmette and Yersin program aims to promote mobility within the Institut Pasteur International Network. The annual call for applications for postdoctoral grants is now open. This call is open to all young researchers wishing realize a research project within an institute of the Network, outside the mainland France.
The 2019 Dedonder Clayton Award
Application deadline : June 17, 2019
The Dedonder Clayton Award honors scientists in Africa and Asia whose outstanding research is contributing to progress in public health, specifically in the field of research on HIV / AIDS and related infections. This award will provide $ 46,000 to support the research to the recipient's team. This Prize is awarded by Pr Stewart COLE, President of the Institut Pasteur and Pr Françoise Barré-Sinoussi, Nobel Prize in Medicine in 2008, and a jury representatives of the Institut Pasteur International Network and the ANRS. The Awards Ceremony will take place during the Institut Pasteur International Network Council of Directors, at Pasteur Center in Cameroon, Yaoundé, the 15th and the 16th of November 2019.
International Course on Antibiotics and Resistance (ICARe)
Date and place: October 19-27, Annecy, France
Application deadline : May 17, 2019
The emergence and spread of bacteria resistant to many drug classes is increasingly threatening all branches of modern medicine. There is currently no international workshops dedicated on improving the stewardship of on antibiotics and the management of antimicrobial resistance. The specific goal of ICARe is to bring leaders in academics and industry together with trained scientists at the daw of their vast experience. Cutting-edge approaches for detection of resistance and antibiotic discovery, chemical optimization, and stewardship, mitigating the development of resistance, will be examined.
Graduation ceremony in Cambodia following the MOOC "Concepts and methods in epidemiology"
MOOC available online until May 19, 2019
A graduation ceremony was held on 29 March 2019 at the University of Health Sciences in Phnom Penh for medical students and interns who had passed the MOOC exam "Concepts and methods in epidemiology". The objective of this course was to provide medical students with the basics of epidemiology, necessary for critical reading of articles. The initiative was carried out with the support of many local partners: Steve Vilhem (doctor, international technical assistant at the French Embassy, USS), Olivier Ségéral (ANRS research doctor), Patrice Piola (head of the epidemiology unit at the Institut Pasteur du Cambodge), Amber Kunkel (post-doctoral fellow at the Institut Pasteur du Cambodge), Phearavin Pheng (epidemiologist, USS research department) and Kennarey Seang (doctor, doctor in epidemiology at the University of California at Los Angeles). The graduation ceremony was attended by Professor Sopheap Seng, Vice-Rector of the University of Health Sciences, Dr Mean Chhi Vun (advisor to the Ministry of Health), Didier Fontenille (Director of the Institut Pasteur du Cambodge), and Arnaud Fontanet (Director of the Epidemiology of Emerging Diseases Unit at the Institut Pasteur and designer of the MOOC). The MOOC is still available online on the platform FUN.
MoU on cooperation signed between Institut Pasteur of Shanghai and Institut Pasteur of Montevideo
On April 17, in the presence of of Prof. ZHANG Yaping, Deputy President of the Chinese Academy of Sciences, and Ms. Sra. María Julia Munoz, Minister of Education and Culture of the Oriental Republic of Uruguay, Prof. TANG Hong, Director General of the Institut Pasteur of Shanghai, Chinese Academy of Sciences (IPS-CAS), and Prof. Carlos Batthyány, Director of the Institut Pasteur of Montevideo (IPM), a “Memorandum of Understanding between the Institut Pasteur de Montevideo and Institut Pasteur of Shanghai, Chinese Academy of Sciences” was signed. According to the memorandum, IPS-CAS and IPM will cooperate in the fields of immunology, virology, vaccines, structural biology, emerging diseases, human and animal health and application development through scientific, educational, cultural and academic exchanges between the two institutions.
Survey on "One Health" practices in the fight against neglected tropical diseases
 Survey available until May 15, 2019
The French-speaking network on neglected tropical diseases (RFMTN) has adopted the One Health approach as its working theme for the years 2019-2020. The Network is currently conducting an online survey, which you are invited to complete if you feel concerned, on the knowledge and practices of the One Health approach in the fight against the six neglected zoonotic tropical diseases. Among the most important neglected tropical diseases, six are zoonoses, for which a One Health approach would offer the best approach for an efficient control of NTDs such as cysticercosis, echinococcosis, leishmaniasis, leptospirosis, rabies, and African trypanosomiasis. One Health or "one health" is an integrated approach to health that focuses on the interactions between animals, humans and their environment. Recognized since 2010 by FAO, OIE and WHO, this approach promotes coordination between different health systems, strengthened communication and synergies that promote economies of scale, all aimed at improving health security.
International Technical Expert - Director of the Institut Pasteur du Cambodge
Application deadline : May 6, 2019
Starting date : September 1, 2019
The French Ministry of Europe and Foreign Affairs announces the position of International Technical Expert - Institut Pasteur du Cambodge. With more than 230 employees, including about 30 expatriates of 10 nationalities, the Institut Pasteur du Cambodge is a Cambodian non-profit institute under Cambodian law, linked to the Institut Pasteur de Paris, under the supervision of the Cambodian Ministry of Health. Its missions are threefold: high-level research in health biology, services (biology laboratory, vaccinations and water and food analyses), training.
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