The Institut Pasteur
               International Network Newsletter
October 2020
The Institut Pasteur International Network mobilized in the surveillance and research on the SARS-CoV-2 virus
In the current context of global health crisis, the spirit of international solidarity which animates the Institut Pasteur International Network has enabled the exchange of information, especially on diagnostic techniques, and support for the institutes so that SARS-CoV-2 molecular tests can be available in due course in every institute. Since mid-February, the institutes of the Institut Pasteur International Network submitted research projects, most often collaborative within the network. Most institutes in Africa, South America and Southeast Asia have been named COVID-19 Reference Centers, some being the WHO Collaborating Centers. Below you will find a selection of news mostly published by the Institutes of the Network.
WHO webiste page on coronavirus
COVID-19 dashboard by the Center for Systems Science and Engineering at Johns Hopkins University
Institut Pasteur disease webpage
The Institut Pasteur and the International Network's mobilization against coronavirus SARS-CoV-2 : ongoing projects and latest news
Institut Pasteur International Network in Asia Pacific’s involvement in the fight against COVID-19
Oswaldo Cruz Fondation (Fiocruz) : study suggests COVID-19 may cause brain damage
Team of international scientists, including the Institut Pasteur in Paris, identify common vulnerabilities across SARS-CoV-2, SARS-CoV-1 and MERS coronaviruses
Institut Pasteur in Paris : innate immunity and fusion of cells infected with SARS-CoV-2
Institut Pasteur de la Guyane : first-ever detection of the Oropouche virus in French Guiana 
An epidemic of dengue-like syndrome started in mid-August 2020 in Saül, a small isolated community in central French Guiana. The National Reference Center (CNR) for arboviruses at the Institut Pasteur de Guyane, called upon by the importance of the attack rate and the negativity of diagnostic tests for dengue, demonstrated by real-time PCR the presence of the Oropouche virus in the serum of 11 patients out of the 15 early samples received at the CNR. This is the first detection of this virus in French Guiana.
The Institut Pasteur de la Guyane studies the spatial epidemiology of yellow fever in Brazil
Yellow fever is a vector-borne disease. From December 2016 to 2020, it caused infections and deaths in humans and monkeys in southeast and southern Brazil. Based on the cases described in human and monkey populations, researchers from the Institut Pasteur de la Guyane and the University of Minas Gerais in Brazil have shown how the temperature, the rain, the predicted density of mammals, the human impact and vaccination coverage explained the occurrence of yellow fever cases in the Brazilian epidemics of 2017-2018.
Institut Pasteur in Paris : new guidelines for treating HBV-positive pregnant women
Hepatitis B is a viral infection that can be fatal. Most chronic forms are caused by mother-to-child transmission. To avoid this transmission, the World Health Organization (WHO) decided to add new recommendations to its existing guidelines. Yusuke Shimakawa, an expert at the Institut Pasteur in Paris, was given the task of producing two systematic reviews to help determine the nature of the new recommendations. He coordinated this research, with the help of WHO, by forming a team including two other Institut Pasteur scientists (Anna L. Funk and Pauline Boucheron) and colleagues in China and Japan.
AIDS: furthering knowledge of natural HIV infection control mechanisms
A further step has just been taken in understanding the mechanisms that allow some individuals to control HIV infection without treatment. A research team led by Dr. Asier Sáez-Cirión (Institut Pasteur) and Dr. Bruno Vaslin (IDMIT, CEA-Inserm-Université Paris Saclay) observed for the first time that the antiviral activity of CD8+ T cells of "controller" macaques infected with the simian immunodeficiency virus (equivalent to HIV for non-human primates) was initially limited in the first two weeks of infection, but increased thereafter. One explanation for this phenomenon would be the early development of highly effective CD8+ memory T cells. This study, supported by ANRS, the MSDAvenir Foundation and the ANR Investments for the Future program, was published in the journal Cell Reports on September 22, 2020.
Institut Pasteur de Madagascar : GeneXpert®, a tool particularly suited to the hospital management of COVID-19 cases
In an article published online in the The Lancet Global Health journal, scientists from the Institut Pasteur de Madagascar, in collaboration with the Ministry of Public Health of Madagascar and the logistical support of the WHO and UNICEF, evaluated the performance of the GeneXpert® assay compared to the real-time PCR used in most laboratories to detect SARS-CoV-2. The results showed the value of using the GeneXpert® platform for the detection of SARS-CoV-2 and the rapid management of patients in the context of a country with limited resources like Madagascar.
TB-Speed still active in the COVID-19 pandemic
In 2019, an estimated 10.0 million people became ill with tuberculosis (TB) worldwide, of which 1.2 million were children. The vast majority of tuberculosis-related deaths occur in children that are not diagnosed and therefore not treated. The TB-Speed Research Project is aiming at contributing to the reduction in childhood mortality from tuberculosis by improving the early detection and treatment of tuberculosis amongst children.The objective of the TB-Speed Research Project is to produce a feasible and cost-effective strategy using innovative diagnosis tools and decentralized approaches improving childhood TB diagnosis developed and available for implementation in high TB-burden settings.
The TB-Speed Research Project is conducted in seven countries: Cambodia, Cameroon, Côte d’Ivoire, Mozambique, Sierra Leone, Uganda and Zambia. In Cambodia, it is conducted by the Clinical Research Group, Epidemiology and Public Health Unit of the Institut Pasteur du Cambodge, in collaboration with the National Tuberculosis Program and several health facilities in the country. It is funded by UNITAID and L’Initiative – Expertise France.
Bilateral Research Cooperation "Springboard" Prize - Africa 
Submission deadline : November 20th, 2020
As part of the Africa 2020 event which will take place throughout France (metropolitan area and overseas territories) from early December 2020 to mid-July 2021, the MESRI is launching a call for tenders which will award several prizes in 2020 intended to highlight and strengthen bilateral research cooperation already initiated between two teams, one French and the other African, by promoting their continuation and amplification around a joint research project lasting two years.
MOOC : Clinical trials in tropical and infectious diseases  
Submission deadline : November 9th, 2020
The general objective of this MOOC is to give health professionals, students and researchers the theoretical and practical bases which will allow them to design clinical trials that meet these criteria. This MOOC, which covers all areas of health, focuses specifically on resource-limited countries. This MOOC, created by the Institut Pasteur in Paris in collaboration with partners involved in clinical trials (Institute of Research for Development, Drugs for Neglected Diseases initiative, etc.), provides the theoretical bases for the clinical investigation and examples of trials in resource-limited countries.
MediLabSecure off-line training on preparedness & response to the health emergency from coronavirus SARS-CoV-2
Offline training to download until December 2020 
From the very beginning and even more during the peak COVID-19 epidemic phase, health personnel is on the front line in the management of the epidemic and with different challenges that, in accordance with their role, include a spectrum of responsibilities ranging from surveillance of cases to clinical management and care of patients with well-known associated risks.
In order to strengthen the surveillance and protection capacities of healthcare workers, the MediLabSecure public health working group has adapted a training course for health staff developed in Italy on Preparedness and Response to the Health Emergency from novel Coronavirus SARS-CoV-2. For more informaton and registration, you can contact mariagrazia.dente@iss.it or mls.training@iss.it
Institut Pasteur de Madagascar : Training on Geographic Information Systems (GIS)  
From November 30th to December 04th, 2020
As part of the RISE project, the Institut Pasteur de Madagascar will organize from November 30th to December 4th, a training course on Geographic Information Systems (GIS) applied to epidemiology and operational activities. GIS are tools for the representation, analysis and characterization of the spatio-temporal component of health phenomena. During the training, participants with a beginner's level on the subject, will familiarize themselves with the use of GIS and will have an introduction to the functions of free and open source software QGIS 3.4.
MOOC : Malaria  
Submission deadline : November 9th, 2020
This MOOC is designed to provide participants with insights into the wide range of disciplines involved, and questions addressed in malaria research. It spans topics from basic cell and molecular biology of malaria parasites to field and hospital-based clinical research on malaria pathology. It covers the latest genomics-based technologies to investigate parasite biology, translational research on new parasite and vector control tools, including drugs and vaccines, as well as malaria epidemiology and clinical research from a public health standpoint. This course is open to everyone interested in malaria. A bachelor of science is recommended to follow this MOOC.
The Institut Pasteur International Network's scientific strategy
The International Pasteur International Network (IPIN) has built its own global scientific strategy to foster a coordinated mobilization of its members on few priority actions, so as to consolidate its positionning as a global health player. 
A Steering Committee (COS RIIP) was established to reflect how to best implementing this scientific strategy, to identify opportunities of partnership between the network members and beyond and to follow up the implemented actions
HKU-Pasteur Research's Pole 20 years anniversary's symposium
To celebrate the 20th Anniversary of HKU-Pasteur Research's Pole, a symposium was held on October 21st. Representatives of the Government, the University of Hong Kong and the Institut Pasteur, as well as the Consul General of France delivered speeches to celebrate the 20th anniversary of the Pole. The scientific session featured presentations from HKU-Pasteur Research's Pole's scientists, who provided an overview of past, current and future research programs.
World Rabies Day: The essential role of the Institut Pasteur de Bangui in the Central African Republic
September 28th, 2020 marked the 14th World Rabies Day. This year, the day was centered on vaccination and collaboration according to the "One world, one health" principle. Rabies still kills humans and animals today in the Central African Republic. Since its creation in 1961, the Institut Pasteur de Bangui has been at the bedside of the Central African population by investing in efforts to prevent and fight against rabies, raise awareness of the disease and strengthen the surveillance and control system. Thanks to its Rabies Center for the Prevention and Treatment of Rabies, the Institut Pasteur de Bangui provides free post-exposure prophylaxis to people in need and thus saves lives.
Immersion in the "venoms and toxins" laboratory at the Institut Pasteur du Maroc
The press devotes an article to the "venoms and toxins" laboratory of the Institut Pasteur du Maroc. In this country very rich in scorpions and snakes, this laboratory is of capital importance. Considered a public health problem by the Moroccan health authorities and classified as "neglected diseases" by the WHO, envenomations from snake bites or scorpion stings have increased in recent years.
RIIP-Info is a monthly newsletter that covers the scientific and institutional news of the Institut Pasteur International Network (IPIN), including strategic partnerships and opportunities of interest such as calls for initiatives, grants, ... It is a selection of articles made by an editorial board from communications proposed or published within the Network. RIIP-Info is distributed to the different members of the Network and their partners, on registration (see link below).
Thank you for your proposals of articles that you can send us at riip-info@pasteur.fr 
To register please click here
The publishing board is comprised of the Vice-President of Communications and Fundraising and the Vice-President of International Affairs and International Network.
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