The Institut Pasteur
               International Network Newsletter
May 2020
The Institut Pasteur International Network mobilized in the surveillance and research on the SRAS-CoV-2 virus
In the current context of global health crisis, the spirit of international solidarity which animates the Institut Pasteur International Network has enabled the exchange of information, especially on diagnostic techniques, and support for the institutes so that SRAS-CoV-2 molecular tests can be available in due course in every institute. Since mid-February, the institutes of the Institut Pasteur International Network submitted research projects, most often collaborative within the network. To date, 21 projects have already been funded. The second call for applications, closed on May 15th, 2020, met with great success since 38 other projects were submitted. Most institutes in Africa, South America and Southeast Asia have been named COVID-19 Reference Centers, some being the WHO Collaborating Centers. Below you will find a selection of news published by the Institutes of the Network (non-exhaustive list).
WHO webiste page on coronavirus
COVID-19 dashboard by the Center for Systems Science and Engineering at Johns Hopkins University
Institut Pasteur disease webpage
The Institut Pasteur and its network collective effort against the COVID-19 pandemic : ongoing projects 
INRS - Armand-Frappier Santé Biotechnologie Research Center : research on a broad-spectrum antiviral against coronaviruses
Fiocruz : novel coronavirus circulated without being detected in Europe and the Americas
HKU-Pasteur Research Pole : identification of viral targets of the antibody response to SRAS-CoV-2 in COVID-19 patients
The Agence Française du Développement approves support for Institut Pasteur in Africa for rapid COVID-19 screening
Revealing how SRAS-CoV-2 hijacks human cells points to drugs with potential to fight COVID-19 and a drug that aids its infectious growth
LuLISA project, bioluminescence as a tool for human diagnostics, from allergy to COVID-19
Institut Pasteur de la Guyane : study shows that resistance to malaria treatments is increasing in the Amazon
Today the recommended therapeutic combinations against malaria are based on a molecule called artemisinin or some of its derivatives. However, the risk that Plasmodium falciparum, the parasite responsible for most cases of malaria, will eventually develop widespread resistance to the drug should be taken seriously. Researchers at the Institut Pasteur de la Guyane studied the impact of a genetic mutation in Plasmodium falciparum on the effectiveness of treatments.
Institut Pasteur of Shanghai, Chinese Academy of Sciences : new connection between some metabolic pathway and regulated cell death in the pathogenesis of inflammatory bowel disease
A study by researchers from the Institut Pasteur of Shanghai, Chinese Academy of Sciences, published on April 1st, in the Journal of Clinic Investigation reveals that the mTOR metabolic pathway plays a central role in the detection and integration of environmental diet signals and microbiota. A diet high in fat and high and proteins contributes to intestinal inflammation and cancer. The study offers a new insight into the pathogenesis of chronic inflammatory bowel disease and the development of therapeutic approaches for these diseases and colorectal cancer.
Achilles’ heel for reseeding of the viral reservoir after stem cell transplantation in people with HIV
Current HIV treatments efficiently block viral multiplication but cannot cure infection as they do not target HIV infected cells. HIV cure or profound HIV remission have been described in three persons with HIV who underwent allogeneic stem cell transplantation to treat severe blood cancers. However, this procedure has not eradicated the virus in other persons. A work led by scientists from the University Medical Center Hamburg and the Institut Pasteur in the context of the ICISTEM international consortium has analyzed the evolution of the immune system in 16 persons with HIV after allogeneic stem cell transplantation. The scientists identified a phase of strong activation of the immune system occurring after the transplant which may provide a window of vulnerability for the reseeding of the HIV reservoir in the expanding donor cells. Their findings are published in the journal Science Translational Medicine on May 6th, 2020. 
Hepatitis B core-related antigen: an alternative to Hepatitis B virus DNA to assess treatment eligibility in Africa
To eliminate hepatitis B virus (HBV) infection, it is essential to scale up testing and treatment. However, conventional tools to assess treatment eligibility, particularly nucleic acid testing (NAT) to quantify HBV DNA, are hardly available and affordable in resource-limited countries. Researchers from the Institut Pasteur therefore assessed the performance of a novel immunoassay, hepatitis B core-related antigen (HBcrAg), as an inexpensive alternative to NAT to diagnose clinically important HBV DNA thresholds and to select patients for antiviral therapy in Africa. Their study shows that HBcrAg might be an accurate alternative to HBV DNA quantification as a simple and inexpensive tool to identify HBV-infected patients in need of antiviral therapy in low- and middle-income countries. This study is part of the NEOVAC project. A second study has also been conducted. 
MOOC : viral hepatitis
Submission deadline : June 27th, 2020
Hepatitis is an acute or chronic inflammation of the liver. Viral hepatitis is most commonly caused by five viruses : A, B, C, D, and E. Some infections will resolve without any serious problems, while others can induce acute liver failure or be chronic and cause fibrosis, cirrhosis, and liver cancer. In this MOOC, you will find the latest developments on the intimate structure and pathophysiology of hepatic viruses and on the epidemiology and clinical courses of hepatitis which may differ in developed and in low and middle income countries. You will learn about prevention of hepatitis A, B and D by immunization and about the most recent developments of efficient treatments of hepatitis B and hepatitis C which allow to get rid of virus B in 90% of patients and to definitely cure hepatitis C in 95% of them. Clear international guidelines are now available for these treatments.
Launch of the MediLabSecure off-line training on preparedness and response to the health emergency from novel coronavirus SRAS CoV-2
Coordinated by the Institut Pasteur, and implemented by five European partner institutes, MediLabSecure is a European Union funded project which aims at reinforcing a multidisciplinary network of laboratories and public health institutions to provide a collective response to emerging viral diseases in the Mediterranean, Black Sea and Sahel Regions. In this context, in order to strengthen the surveillance and protection capacities of healthcare workers, the MediLabSecure public health working group coordinated by the Istituto Superiore di Sanità (ISS) has adapted a training course for health staff developed in Italy on Preparedness and Response to the Health Emergency from novel Coronavirus SRAS CoV-2 structured into three units: features of SRAS CoV-2 emergency; surveillance, identification and management of suspects and cases and information for the health personnel on prevention, identification and control in clinical and community settings.
Call for projects Institut Pasteur - Fiocruz - USP 
Submission deadline : July 20th, 2020
The call for proposals for projects involving the Institut Pasteur International Network, Fundação Oswaldo Cruz (Fiocruz) and the Universidade de São Paulo (USP) is now open.
The main objective is to facilitate the collaborations in priority areas of research and public health programs, particularly in the framework of the tripartite agreement signed between Institut Pasteur, Fiocruz, USP and FUSP.
The proposals should bring together researchers or teams from at least one institute member of the Institut Pasteur International Network, of the Fundação Oswaldo Cruz and of the Universidade de São Paulo.
French National Research Agency : Call for Research-Action projects on COVID-19
Submission deadline : October 28th, 2020
In the continuity of the Flash call launched in March 2020, the French National Research Agency (ANR) is launching a new call for Research-Action projects on COVID-19 (coronavirus disease 2019) responsible for an epidemic that started at the end of 2019 and caused by the coronavirus pathogen SRAS-CoV-2. Open continuously until October, 28th 2020 and focused on WHO recommendations, this call aims to rapidly support the scientific communities mobilized on COVID-19 in an emergency context.
Pasteur Talent Network Awards 2020  
Submission deadline : July 17th, 2020
In order to support the career development of young scientists promising to become future leaders within the International Network, Institut Pasteur is pleased to announce the opening of the call for nomination for the Pasteur Network Talent Award 2020.
Calmette & Yersin Postdoctoral Grant 
Submission deadline : July 24th, 2020
The Calmette and Yersin program aims to promote mobility within the Institut Pasteur International Network. The annual call for applications for doctoral grants is now open. This call is open to all student wishing realize their thesis within an institute of the Network, outside the mainland France.
UNESCO-MERK Foundation : STEM program  
Submission deadline : August 30th, 2020
Empowering women through education is an important factor in promoting the economic well-being of Africans. This STEM program (Science, Technology, Engineering and Mathematics) partners with global and local institutions and organizations to empower women and young people in the areas of science and technology. Education as an important factor in promoting economic well-being in Africa.
Institut Pasteur International Network 2020 logo: the Network Alliance around a new "φ"siognomy to display strength, modernity, cooperation and unfailing mobilization
In its desire to modernize its image and strengthen its influence in France and abroad, the Institute Pasteur has changed its image through a new logo inaugurated at the end of February. The International Department naturally took up this identity challenge,in collaboration with the Communication and Sponsorship Department and the General Management, to propose an adaptation for the Institut Pasteur International Network (IPIN). A true support to the brand image of any association, institution or organization, the logo plays a major role in the transmission of our foundation's values. It is part of its visual identity and occupies a privileged and strategic place on all communication media. Following in the footsteps of its "predecessor", the 2020 logo of the Institut Pasteur International Network is still composed of the acronym "φ" drawn from a purer line with a radiance of small spheres around the world representing international cooperation, team cohesion and the mobilization of all the network. This new logo thus symbolizes interconnections with the local sphere, regional achievements and international issues.
The new logo will be implemented as new documents evolve, starting with the updating of the IPIN map.
Fawzi Derrar, new President of the Institut Pasteur d'Algérie
Dr. Fawzi Derrar has been appointed President of the Institut Pasteur d'Algérie since March 5th, 2020.
Prior to serving as President of the Institut Pasteur, he served in the same institution where he led during 17 years a key laboratory (Viral Respiratory Laboratory with the National Influenza Centre). His research includes topics of human and human-animal interface influenza and RSV; and the assessment of influenza vaccines and antivirals impact. His research also covered Coronaviruses (he has been currently conducting a large study with WHO on circulation of MERS-CoV in dromadory camels in the south of Algeria since 2015). Dr. Derrar holds a physician degree (1998) a Microbiology degree (2003) and a degree in Statistics for Medicine and Biology (2005) .
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