The Institut Pasteur
               International Network Newsletter
September 2020
The Institut Pasteur International Network mobilized in the surveillance and research on the SARS-CoV-2 virus
In the current context of global health crisis, the spirit of international solidarity which animates the Institut Pasteur International Network has enabled the exchange of information, especially on diagnostic techniques, and support for the institutes so that SARS-CoV-2 molecular tests can be available in due course in every institute. Since mid-February, the institutes of the Institut Pasteur International Network submitted research projects, most often collaborative within the network. Most institutes in Africa, South America and Southeast Asia have been named COVID-19 Reference Centers, some being the WHO Collaborating Centers. Below you will find a selection of news published by the Institutes of the Network (non-exhaustive list).
WHO webiste page on coronavirus
COVID-19 dashboard by the Center for Systems Science and Engineering at Johns Hopkins University
Institut Pasteur disease webpage
The Institut Pasteur and the International Network's mobilization against coronavirus SARS-CoV-2 : ongoing projects and latest news
Hong Kong University-Pasteur Research Pole : discovery of new targets of SARS-CoV-2 humoral immune response
COVID-19 – an intranasal lentiviral vaccine in development provides significant protection in animals
Oswaldo Cruz Fondation (Fiocruz) : study shows action of molecules on the new coronavirus
Hong Kong University-Pasteur Research Pole : systems biology approach to determine host immune responses to COVID-19
Oswaldo Cruz Fondation (Fiocruz) : cases of chikungunya have fallen with the Wolbachia method
The randomized controlled trial (RCT) “Applying Wolbachia to Eliminate Dengue (AWED)” lasted three years and was carried out in an area inhabited by about 321,000 people. In Brazil, the Wolbachia Method is led by Fiocruz, in a partnership with the Ministry of Health and with the support of local governments. The actions were kick-started in Rio de Janeiro and Niterói, in an area with 1.3 million inhabitants. In Niterói, preliminary data already point to a reduction of 75% of chikungunya cases in the areas that received the Aedes aegypti with Wolbachia, when compared with areas that did not.
Guadeloupe : more information about the demographic history of Aedes albopictus, vector of Chikungunya
With the help of a genetic structure analysis carried out on 25 Ae. albopictus mosquito populations covering all continents, scientists demonstrate that the demographic history of Ae. albopictus has shaped the vector competence of these populations. This information is essential to better estimate the risks of chikungunya emergence in Europe.
Scientists reveal the structure of a protein that is key for tuberculosis virulence
Researchers from the Institut Pasteur de Montevideo, in collaboration with Argentinian scientists, managed to understand the workings of a protein from the bacterium that causes tuberculosis, which is key to regulating the virulence of the pathogen. The findings — published in Nature Communications on July 24 — provide valuable tools to fight the disease, because this protein may be a target for new anti-tuberculosis drugs.
Institut Pasteur de Madagascar: highlighting the major role of An. coustani in the transmission of malaria in the north-west of the country
Malaria in Madagascar is mainly due to Plasmodium falciparum and Plasmodium vivax. These two Plasmodium species are mainly transmitted by Anopheles arabiensis and Anopheles funestus throughout the country. For many years, a zoophilic mosquito Anopheles coustani has been suspected to act as a secondary vector, due to its abundance in places with malaria and absence of An.arabiensis and An. funestus.
The work done by Jessy Marlène Goupeyou-Youmsi, Calmette-Yersin PhD fellow, at the Institut Pasteur de Madagascar revealed that An.coustani acted as the main malaria vector in Miarinarivo, a village located in the North-West region of Madagascar. This is the first time that this mosquito species is found to be a major local vector in Madagascar. Furthermore, the An.coustani population in Miarinarivo exhibited an unexpected indoor biting behavior, while it was mainly outdoor biting in the close by village, Ambohitromby. This result is important to guide further adapted vector control measure as IRS (Indoor Residual Spray) and use of insecticide treated bed nets in Miarinarivo and possibly elsewhere.
Pasteur Center in Cameroon : first total diet study in sub-Saharan Africa
This large-scale total diet study has been coordinated by the FAO (Food and Agriculture Organization of the United Nations) in collaboration with the WHO (World Health Organization) and the Pasteur Center in Cameroon.
In total, 4,020 samples, covering more than 90% of the food of 7,291 households were collected in two regions of Benin, Cameroon, Mali and Nigeria. Foods, prepared as consumed, were analyzed for 872 chemicals considered by expert laboratories selected by FAO. The results are detailed in an article published by The Lancet Planetary Health on July 16th, 2020.
French National Research Agency : Call for Research-Action projects on COVID-19
Submission deadline : October 28th, 2020
In the continuity of the Flash call launched in March 2020, the French National Research Agency (ANR) is launching a new call for Research-Action projects on COVID-19 (coronavirus disease 2019) responsible for an epidemic that started at the end of 2019 and caused by the coronavirus pathogen SARS-CoV-2. Open continuously until October, 28th 2020 and focused on WHO recommendations, this call aims to rapidly support the scientific communities mobilized on COVID-19 in an emergency context.
Christophe Mérieux Prize 2021  
Submission deadline : November 20th, 2020
Since 2007, the Fondation Christophe et Rodolphe Mérieux has given out an annual scientific ‘Grand Prize,’ called the “Christophe Mérieux Prize” to a researcher or research team studying infectious diseases in a developing country.
The winner is chosen by the Institut de France based on proposals from the Mérieux Foundation, which submits a list of researchers that were identified in the field.
This 500,000 euro prize is designed to support research on infectious disease in developing countries and reward research teams working permanently in these countries.
"Climat et Impacts" Days : call for abstracts 
Submission deadline : October 23rd, 2020
The 6th edition of the "Climat et Impacts" conference will take place on November 23rd, 24th and 25th, 2020 on the premises of the University of Paris-Saclay (École Centrale-Supélec, Orsay).
This new edition of the "Climat et Impacts" conference aims to bring together scientific expertise on current and past climate variability, its causes, its impacts on ecosystems and its repercussions on past and present human societies.
Pasteur Courses : Vaccinology
Inscription deadline : October 31th, 2020
This four-week course presents an integrated overview of vaccinology, from public health data and scientific results justifying the development of a vaccine up to its delivery to the populations in the context of industrialized and developing countries.
Only 14 participants will be selected, including a final selection step by visio interview.
MOOC : Clinical trials in tropical and infectious diseases  
Inscription deadline : October 31th, 2020
The general objective of this MOOC is to give health professionals, students and researchers the theoretical and practical bases which will allow them to design clinical trials that meet these criteria. This MOOC, which covers all areas of health, focuses specifically on resource-limited countries. This MOOC, created by the Institut Pasteur in Paris in collaboration with partners involved in clinical trials (Institute of Research for Development, Drugs for Neglected Diseases initiative, etc.), provides the theoretical bases for the clinical investigation and examples of trials in resource-limited countries.
Medilabsecure off-line training on preparedness & response to the health emergency from coronavirus Sars-CoV-2
Inscription deadline : October 31th, 2020
From the very beginning and even more during the peak COVID-19 epidemic phase, health personnel is on the front line in the management of the epidemic and with different challenges that, in accordance with their role, include a spectrum of responsibilities ranging from surveillance of cases to clinical management and care of patients with well-known associated risks.
In order to strengthen the surveillance and protection capacities of healthcare workers, the MediLabSecure public health working group has adapted a training course for health staff developed in Italy on Preparedness and Response to the Health Emergency from novel Coronavirus SARS-CoV-2
Dr Jean-Michel Héraud, appointed to the rank of knight of the Ordre National de Madagascar
On August 19th, 2020, Dr. Jean-Michel Héraud, head of the Virology Unit at the Institut Pasteur de Madagascar, was appointed to the rank of knight of the Ordre National de Madagascar. This award represents the recognition by the authorities of this country for his commitment to the Institut Pasteur in the service of the health of the populations during the 12 years that he spent in Madagascar. He left the Institut Pasteur de Madagascar on August 30th to join the Institut Pasteur de Dakar.
The Rotary Club funds an ADAGIO antibiogram reader for the Institut Pasteur de Bangui
The Institut Pasteur de Bangui is currently one of the few establishments located in the Central African Republic able to perform medical bacteriology analyzes for diagnosis and epidemiological purposes. As such, it plays an observatory role for microbiological trends and emergencies. For more than 10 years, he has observed the emergence and extension of the phenomenon of resistance of pathogenic bacteria to antibiotics. Thanks to the Rotary Club Paris Quai d'Orsay, the Institut Pasteur de Bangui was able to acquire an Adagio antibiogram reader from the company Bio-Rad, which will enable it to strengthen its monitoring and diagnosis capacities.
RIIP-Info is a monthly newsletter that covers the scientific and institutional news of the Institut Pasteur International Network (IPIN), including strategic partnerships and opportunities of interest such as calls for initiatives, grants, ... It is a selection of articles made by an editorial board from communications proposed or published within the Network. RIIP-Info is distributed to the different members of the Network and their partners, on registration (see link below).
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The publishing board is comprised of the Vice-President of Communications and Fundraising and the Vice-President of International Affairs and International Network.
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