The Institut Pasteur
               International Network Newsletter
November 2020
The Institut Pasteur International Network mobilized in the surveillance and research on the SARS-CoV-2 virus
In the current context of global health crisis, the spirit of international solidarity which animates the Institut Pasteur International Network has enabled the exchange of information, especially on diagnostic techniques, and support for the institutes so that SARS-CoV-2 molecular tests can be available in due course in every institute. Since mid-February, the institutes of the Institut Pasteur International Network submitted research projects, most often collaborative within the network. Most institutes in Africa, South America and Southeast Asia have been named COVID-19 Reference Centers, some being the WHO Collaborating Centers. Below you will find a selection of news mostly published by the Institutes of the Network.
WHO webiste page on coronavirus
COVID-19 dashboard by the Center for Systems Science and Engineering at Johns Hopkins University
Institut Pasteur disease webpage
The Institut Pasteur and the International Network's mobilization against coronavirus SARS-CoV-2 : ongoing projects and latest news
The Institut Pasteur de Corée presented cross-border scientific collaboration framework facilitating clinical development of COVID-19 therapeutics
Oswaldo Cruz Fondation (Fiocruz) : study shows eight lineages of the new coronavirus in the Amazonas state
COVID-19: neutralizing immune response lasts longer in women than in men
Hong Kong University-Pasteur Research Pole : evaluation of a SARS-CoV-2 surrogate virus neutralization test for detection of antibody in multiple species
Lauching of the PIC label : Pasteur International Courses
The Institut Pasteur and the Pasteur International Network association (PINA) launch the official Pasteur International Courses “PIC” label for the Institut Pasteur International Network’s (IPIN) training programmes, workshops and Massive Open On-Line Courses (MOOCs).
This programme, coordinated by the Education Department, the International Department and Pasteur International Network association, will strengthen the visibility and attractiveness of education programmes, digital and onsite, across the Network.
It will also promote Institut Pasteur courses/MOOC in local and regional universities, developing partnerships with other stakeholders and contributing to the career development of future scientific and public health leaders.
Toward an integrated surveillance of potential zoonotic Betacoronaviruses in the wild animal value chain of Cambodia
The COVID-19 pandemic once again draws attention on zoonotic diseases and their impact on public health. Over the last 20 years three of the major epidemics (Severe Acute Respiratory Syndrome – SARS, Middle East Respiratory Syndrome – MERS and the COVID-19) shows that potential transmission of pathogens from animal to humans are a serious threat to public health.
Nevertheless, wildlife trade and bushmeat consumption remain popular throughout Southeast Asia, is important economically but also may increase the risk of transmission of pathogens from wildlife to humans. Therefore, the French Research Agency (ANR), Region Occitanie and the Pasteur Foundation Asia jointly funded the ZooCoV international research project led by CIRAD (International Center of Research in Agronomy for Development) to better address the risk this trade and consumption practices represent for the local population in Cambodia. The project started in April 2020 for an initial period of 18 months.
Beginning of the plague season in Madagascar : what has been learnt from previous events ?
Throughout human history, plague has proven its capacity to disrupt human society and its socioeconomic and cultural impacts. Plague is endemic in Madagascar, with a number of reported human cases ranging from 280 to 600 per year. A two days’ workshop was organized in July 2018 at the Institut Pasteur (Paris), bringing together some of the plague specialists around the world and potential funding institutions (54 participants from 12 countries) to identify the activities of priority, to move forward key translational and operational research activities. Human (public health and medical sciences), animal (wild & peri-domestic) and environmental components were addressed through a “One health” approach. Resolutions from this workshop coupled with public health priorities identified during the outbreak allowed to develop from now two projects.
Unusual prevalence of Klebsiella pneumoniae in spontaneous community-acquired bacterial meningitis in adults in the Caribbean French West Indies
An unusual prevalence of Klebsiella pneumoniae (24%) was observed in 25 adults admitted to the intensive care units of two University Hospitals in the French West Indies, for spontaneous community-acquired bacterial meningitis. All tested isolates had several prominent features of hypervirulent isolates. 
Zika outbreaks fueled by virus-permissive mosquitoes
What factors facilitate the emergence of a previously unknown virus in the human population? Scientists from the CNRS, the Institut Pasteur and the IRD, in collaboration with the Institut Pasteur International Network and with several other institutions worldwide, have helped answer that question for the Zika virus. Their study sheds light on regional and continental disparities in Zika outbreaks and explains why there have been no major outbreaks in Africa.
Considering the diagnosis of hepatitis E in children living with HIV and suffering from severe acute malnutrition in the Central African Republic
The first documented case of a 36 month old malnourished child co-infected with HIV and hepatitis E in the Central African Republic demonstrates that this co-infection in a child suffering from severe acute malnutrition can accelerate a fatal outcome. It is important to test for both hepatitis E and intestinal parasites in malnourished children living with HIV to avoid possible fatal complications.
Grants from the Pierre Ledoux Foundation - Jeunesse Internationale
Submission deadline : December 11th, 2020
The Pierre Ledoux Foundation - Jeunesse Internationale, under the aegis of the Fondation de France, is launching, with the support of the Institut Pasteur, the 42nd call for applications intended to finance stays in an institute of the Institut Pasteur International Network in the field of biomedical research, for the benefit of young French students from Universities and Schools engaged in the training of young biologists, doctors, pharmacists and veterinarians. The grants offered, lasting from 3 to 10 months, will allow the laureates to enrich their professional and human training with field and laboratory experience acquired in the field of infectious or parasitic diseases in a developing country within the Institut Pasteur International Network. For any further information contact valerie.choumet@pasteur.fr
4-year Research Group within the Institut Pasteur International Network 
Submission deadline : February 12th, 2021
To encourage the development of ambitious research programmes, and to strengthen scientific leadership skills of promising researchers across the Institut Pasteur International Network (IPIN), Institut Pasteur will support the creation of 4-year Research Groups (G4) in these IPIN institutes.
MOOC : Malaria  
Submission deadline : December 7th, 2020
The general objective of this MOOC is to give health professionals, students and researchers the theoretical and practical bases which will allow them to design clinical trials that meet these criteria. This MOOC, which covers all areas of health, focuses specifically on resource-limited countries. This MOOC, created by the Institut Pasteur in Paris in collaboration with partners involved in clinical trials (Institute of Research for Development, Drugs for Neglected Diseases initiative, etc.), provides the theoretical bases for the clinical investigation and examples of trials in resource-limited countries.
MOOC : Tuberculosis 
Submission deadline : February 17th, 2021
Tuberculosis has been a scourge of humanity for hundreds of years. In the 18th and 19th centuries, tuberculosis was called the white plague and in some countries in Europe and the US was responsible for 20% or more of all deaths.
To provide an up-to-date overview of the disease, the Institut Pasteur has created a MOOC dedicated to Tuberculosis. The course aims at providing a broad overview of the current state of knowledge about tuberculosis for physicians, nurses and other health and public health workers, microbiologists, pharmacists, researchers and students. It will serve as a valuable update for people working with tuberculosis, a thorough introduction for those who are new to the field and a great opportunity for all those who want to broaden their understanding of the disease.
MediLabSecure off-line training on preparedness & response to the health emergency from coronavirus SARS-CoV-2
Offline training to download until December 2020 
From the very beginning and even more during the peak COVID-19 epidemic phase, health personnel is on the front line in the management of the epidemic and with different challenges that, in accordance with their role, include a spectrum of responsibilities ranging from surveillance of cases to clinical management and care of patients with well-known associated risks.
In order to strengthen the surveillance and protection capacities of healthcare workers, the MediLabSecure public health working group has adapted a training course for health staff developed in Italy on Preparedness and Response to the Health Emergency from novel Coronavirus SARS-CoV-2. For more informaton and registration, you can contact mariagrazia.dente@iss.it or mls.training@iss.it
Report on the 52nd International Network Council of Directors meeting – lessons to be drawn from the COVID-19 pandemic in the International Network
The 52nd meeting of the Institut Pasteur International Network Council of Directors was held last week. Because of the extraordinary events this year, the latest meeting took place entirely on a remote basis.
The physical absence of the participants did not hinder the presentations, discussions and good humor of the meeting, which was greatly facilitated by simultaneous interpretation into English and French. More than a hundred people logged into each session.
The program of presentations focused on the lessons that can be drawn from the handling of the COVID-19 pandemic within the International Network. Three parts spread over three days provided an opportunity to make an initial assessment of the institutes' response to the outbreak in their respective countries, while also reflecting on the role of the International Network and the contribution it can make in such a crisis situation. The final day featured an analysis of the research carried out by the International Network to tackle the virus and a presentation of recommendations from the Scientific Steering Committee designed to improve preparedness for future outbreaks.
Tsarasoa Malala Andrianinarivomanana, winner of the "Young Talents - Sub-Saharan Africa - 2020" award from the "For Women in Science" program of the L’Oréal Foundation
Tsarasoa Malala Andrianinarivomanana, PhD student, has been hosted since 2018 within the Medical entomology unit of the Institut Pasteur de Madagascar to carry out her research work. She is one of the 20 laureates who have just received the prize of the "For Women in Science" program from the L’Oréal Foundation in the "Young Talents Sub-Saharan Africa 2020" category. The young researcher was distinguished for her studies on Anopheles coustani, a species of mosquito recently suspected of contributing to the transmission of malaria in Madagascar as well as in sub-Saharan Africa.
Researchers from Hong-Kong University - Pasteur Research Pole and Institut Pasteur of New Caledonia are winners of the "Pasteur Network Talent Award" 2020 
Pasteur Network Talent Award s» 2020 were presented on Thursday 19 November 2020 to Dr Sophie Valkenburg and Dr Roman Thibeaux by Pr Pierre-Marie Girard, Institut Pasteur vice-president international Affairs and by Prof. Stewart Cole, President of The Institut Pasteur.
For this fourth edition of the prizes, the international jury has decided to reward Dr Sophie Valkenburg from Hong-Kong University-Pasteur Research Pole for her work on protective immune responses against viral infections, including influenza, with a view to developing new vaccines. Dr Roman Thibeaux from Institut Pasteur de Nouvelle-Calédonie was rewarded for his studies on environmental leptospirosis, a neglected bacterial disease, endemic in tropical and subtropical areas.
WHO unveils team of 10 scientists to trace COVID-19 origins
The World Health Organization has unveiled the names of 10 scientists set to travel to Wuhan “as soon as possible” to trace the origins of Sars-Cov-2.
The international team will work with Chinese experts to investigate how Covid-19 jumped from animals to humans. Since the virus first emerged experts have been keen to track its origins, with the WHO identifying this a “priority research area” in February and sending a preliminary “scouting mission” to China over the summer. Vladimir Dedkov, an epidemiologist at the Institut Pasteur de Saint-Petersburg and Dominic Dwyer, a medical virologist and Director of the Centre for Infectious Diseases and Microbiology Laboratory Services at Westmead Hospital in Sydney who studied HIV at the Institut Pasteur in Paris, are part of the team. 
RIIP-Info is a monthly newsletter that covers the scientific and institutional news of the Institut Pasteur International Network (IPIN), including strategic partnerships and opportunities of interest such as calls for initiatives, grants, ... It is a selection of articles made by an editorial board from communications proposed or published within the Network. RIIP-Info is distributed to the different members of the Network and their partners, on registration (see link below).
Thank you for your proposals of articles that you can send us at riip-info@pasteur.fr 
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The publishing board is comprised of the Vice-President of Communications and Fundraising and the Vice-President of International Affairs and International Network.
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